David Thorpe, MD, PhD

Personal Information
Assistant Research Scientist
(520) 626-8467

David Thorpe, MD, PhD, is an Assistant Research Scientist at the Sarver Heart Center in Clinical Sciences and Translational Medicine.  He is currently working on the proteomics of heart failure with a multisite clinical study of more than 1,300 subjects, and “disease in a dish” approaches of bench science such as iPSC – inducible pluripotent stem cells – from people with and without heart disease.

He brings over 30 years of biotech, pharmaceutical (Selectide to Sanofi in Tucson) and academic experience including 12 years each in cardiovascular, diabetes and inflammatory disease research with emphasis of 8 years on guanylate cyclases, plus anticoagulants (with Xa IND), myosin & other heart failure targets, 8 years each on incretins (mainly GLP-1) and chemokines.  He has published work on drug target discovery and validation using chemical tools, combinatorial chemistry, drug discovery and worldwide patents for experimental chemokine-directed anti-inflammatory drugs.

Returning to his Wildcat roots, Dr. Thorpe was a Principal Investigator at the UA Heart Center from 1990 – 1992, executing two grants from American Heart Association & the Arizona Disease Control Research Commission on guanylate cyclases, proteins important to the actions of nitrates and natriuretic peptides.

Dr. Thorpe earned his PhD in Molecular Physiology and Biophysics from Vanderbilt University, Nashville, TN, and his MD from Vanderbilt University School of Medicine, Nashville, TN. He earned his BS in Psychology from Arizona State University in Tempe, AZ.