Charles C. Oh, MD

Personal Information
Chief, Cardiology, Phoenix VA Healthcare System
Assistant Clinical Professor of Medicine, University of Arizona - Phoenix
(602) 277-5551
charles.oh@va.gov

Charles Oh, MD, is Chief of the Cardiology Division with the Phoenix VA Health Care System as well as a Clinical Assistant Professor of Medicine at the University of Arizona – Phoenix Campus. Prior to establishing his lab at the Phoenix VA, Dr. Oh completed his residency in internal medicine at the Mayo Clinic in Rochester, a cardiology fellowship at the Oregon Health and Science University (OHSU) in Portland, where he also served as an Assistant Professor of Medicine.

Dr. Oh’s laboratory focus is on the role of saturated fatty acids (SFA) on the development of diabetic cardiomyopathy. Three abstracts and two papers have been published on the activation of the p38α mitogen-activated protein kinase – dependent signaling pathway by saturated fatty acids leading to increased apoptosis of cardiomyocytes that may underlie diabetic cardiomyopathy in collaboration with Drs. Migrino and Reaven at the Phoenix VA and Dr. Kent Thornburg at OHSU. Ultimately their goal is translate the in vitro findings to potential therapies blocking this SFA-induced signaling initially in animal models, then eventually in human trials. 

 

EDUCATION

B.S.: University of California, Los Angeles, Los Angeles, CA, 1987

  Major: Psychobiology

M.D.: Medical College of Wisconsin, Milwaukee, WI, 1994

Residency: Mayo Clinic, Internal Medicine, Rochester, MN, 1997

Cardiology Fellowship: Oregon Health and Science University (OHSU), Portland, OR, 2001

 

SELECTED ABSTRACTS & PUBLICATIONS

Oh CC, Nguy MQ, D CS, Migrino RQ, Thornburg K and Reaven P. p38alpha mitogen-activated kinase mediates cardiomyocyte apoptosis induced by palmitate. Biochemical and biophysical research communications. 2014 Jul 18;450(1):628-98.

p38α MAPK mediates saturated fatty acid-induced cardiomyocyte apoptosis (547.19). C Oh, M Nguy, R Migrino, K Thornburg, D Schwenke, P Reaven The FASEB Journal 28 (1 Supplement), 2014;547.19.

Quantification of LVEF≤ 35% misclassification by 2D-echocardiography as compared to cardiac magnetic resonance in coronary artery disease: implications for AICD therapy.  DJ Parrington, A Saremi, SV Girotra, S Dev, C Oh, CL Scott, RQ Migrino.  Journal of Cardiovascular Magnetic Resonance, 2012;14, 1-2.

Palmitate Induces Dose-Dependent Apoptosis in Chick Embryo Cardiomyocytes CC Oh, J Levy, W Ma, P Reaven, R Migrino, D Franco, K Thornburg.  Circulation  Research, 2012;111 (4).

Oh CC, Klein JD, Migrino RQ, Thornburg KL.  Growing collateral arteries on demand. Recent Pat Cardiovasc Drug Discov. 2011 Sep 1;6(3):189-98.