Research

Qin Chen, PhD

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Professor, Department of Pharmacology, College of Medicine
(520) 626-9126
qchen@email.arizona.edu

Janis M. Burt, PhD

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Research Professor of Physiology & Surgery
(520) 626-6833
jburt@u.arizona.edu

Heddwen Brooks, PhD

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Professor, Dept. of Physiology/Pharmacology
Chair, Graduate Interdisciplinary Program
(520) 626-7702
brooksh@email.arizona.edu

Dr. Heddwen Brooks received her PhD from Imperial College, University of London and did her post-doctoral training at NIH with Dr. Mark Knepper studying the role of vasopressin in regulating renal function and with Dr. Andrea Yool (UA) identifying novel inhibitors for aquaporins. Heddwen is currently Professor of Physiology and Pharmacology, and Chair of the Graduate Interdisciplinary Program in Physiological Sciences, at the University of Arizona.

Heddwen is a renal physiologist and has developed microarray technology to address in vivo signaling pathways involved in the hormonal regulation of renal function. Current areas of research in the Brooks Laboratory are focused on importance of sex differences in the onset of postmenopausal hypertension and diabetic kidney disease and identifying new therapies for polycystic kidney disease and lithium-induced nephropathy. She is a member of the Sarver Heart Center, the Arizona Center on Aging, and BIO5.

Heddwen is very active in the American Physiological Society at a National and International level; she received the prestigious American Physiological Society Lazaro J. Mandel Young Investigator Award (2007) and the American Physiological Society Renal Young Investigator Award (2009) and has served as Chair of the Renal Section of the American Physiological Society. She serves on the Editorial Board of AJP-Renal Physiology as well as on study sections of the National Institutes of Health and the American Heart Association. She is currently an Associate Editor for AJP - Regulatory, Integrative and Comparative Physiology, a member of the American Physiological Society’s Education Committee, and a recent past member of the Nephrology Merit Review Board for the Department of Veterans’ Affairs.

Margaret Briehl, PhD

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Associate Professor of Pathology
(520) 626-6827
mmbriehl@email.arizona.edu

Ann L. Baldwin

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Professor of Physiology
(520) 626-6264
abaldwin@u.arizona.edu

Parker Antin, PhD

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Professor of Cellullar and Molecular Medicine
Associate Dean for Research, College of Agriculture and Life Sciences
(520) 626-6382
pba@u.arizona.edu

The Antin Lab focuses on understanding the molecular regulation of early developmental processes in vertebrate embryos, primarily the chicken embryo as a model organism. Present projects are focused on mechanisms regulating epithelial-mesenchymal transition (EMT) during gastrulation, endothelial cell development, cardiac myogenesis, and developing genomic and computational tools. The lab hosts the GEISHA high throughput in situ hybridization gene expression project.

 

Marietta Anthony, PhD

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The Critical Path Institute, Associate Director, Center for Education and Research on Therapeutics
(301) 762-7650
manthony@c-path.org

Craig Aspinwall, PhD

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Associate Professor of Chemistry
(520) 621-6338
aspinwal@email.arizona.edu

Maria Altbach, PhD

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Associate Professor of Radiology
(520) 626-5332
maltbach@email.arizona.edu

Carol Gregorio, PhD

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Vice Dean for Innovation and Development, University of Arizona College of Medicine - Tucson
Chair, Department of Cellular and Molecular Medicine
Professor of Molecular, Cell Biology and Anatomy;
Co-Director, and Luxford/Schoolcraft Endowed Professor of Cardiovascular Disease Research, UA Sarver Heart Center
Director, UA Sarver Heart Center Molecular Cardiovascular Research Program
(520) 626-8113
gregorio@u.arizona.edu

Carol Gregorio, PhD, co-director of the UA Sarver Heart Center and the Luxford/Schoolcraft Endowed Professor of Cardiovascular Disease Research, directs the Molecular Cardiovascular Research Program at the UA Sarver Heart Center and College of Medicine - Tucson. She also is Vice Dean for Innovation and Development for the College of Medicine and chairs the Department of Cellular and Molecular Medicine. As a basic scientist, she has a special research interest in the contractile proteins of heart muscle. Not only has she made major contributions to the understanding of heart muscle abnormalities, but she also has been an integral part of the UA College of Medicine’s goal to strengthen its translational research and the UA Sarver Heart Center’s effort to recruit other outstanding basic scientists.

Dr. Gregorio’s laboratory research is focused on identifying the components and molecular mechanisms regulating actin architecture in cardiac and skeletal muscle during normal development and disease. The research objectives of the laboratory can be broadly summarized as follows:

  • Understanding the cellular mechanisms involved in the assembly, regulation and maintenance of contractile proteins in cardiac muscle in health and disease;
  • Deciphering the mechanisms critical for precisely specifying and maintaining the lengths of actin filaments. Actin is an indispensable structural element of cells and is the major component of heart muscle. Changes in actin, caused by genetic mutations, which have been identified in humans, are a frequent cause of several forms of cardiomyopathy. The research team is determining how genetic defects in this protein affect muscle force generation and muscle contraction, leading to sudden cardiac death.
  • Discovery of novel models of de novo cardiac muscle assembly, with special emphasis on differentiating murine embryonic stem (ES) cells to study all stages of heart muscle development.

A native of New York, Dr. Gregorio obtained her bachelor and master degrees from SUNY Buffalo and her PhD from Roswell Park Cancer Institute in New York. She did her postdoctoral research at the Scripps Research Institute in La Jolla, Calif. She joined the UA faculty in 1996. She is a member of the BIO5 Institute.

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