Clinical Trials at University of Arizona Sarver Heart Center

Please complete a Cardiology Research Registry Information Form to learn about new clinical research studies for which you may be eligible.

What is a Clinical Trial?
Be Part of Something Big to Help Beat Heart Disease

The Sarver Heart Center Biorepository is up and running

This won’t take much – just three tablespoons of your blood, about the amount taken during a standard blood draw. This small amount will help us ask bigger questions and get better answers as we move toward a future free of heart disease and stroke. You don’t have to have heart disease to be part of this big venture. You just need to be at least 18 years old. Learn more.

You may be eligible to enroll in the following clinical trials @ Sarver Heart Center

For more information, please contact Catherine MacDonald, BScN, MBA, clinical research manager, or 520-626-4899, or Lizzette Marquez, RN, MS, research nurse, at or 520-626-5431.

ANG-(1-7) IN HF - Nancy K. Sweitzer, MD, PhD

Angiotensin (1-7) Treatment to Improve Cognitive Functioning in Heart Failure Patients

CardioMEMS HF System - Jennifer Cook, MD

Post-approval Study for Heart Failure Patients

COMMANDER HF - Jennifer Cook, MD

A Randomized, Double-blind, Event-driven, Multicenter Study Comparing the Efficacy and Safety of Rivaroxaban With Placebo for Reducing the Risk of Death, Myocardial Infarctionor Stroke in Subjects With Heart Failure and Significant Coronary Artery Disease Following an Episode of Decompensated Heart Failure

DCM Consortium- Nancy K. Sweitzer, MD, PhD

Blood draw, questionnaire & possible genetic counseling

LIVE-HCM - Jil C. Tardiff, MD, PhD

Lifestyle and Exercise in Hypertrophic Cardiomyopathy " LIVE-HCM"

Lumason - Raj Janardhanan, MD

A Prospective Multicenter Phase III Clinical Evaluation of the Safety and Efficacy of Lumason™/SonoVue® in Subjects Undergoing Pharmacologic Stress Echocardiography with Dobutamine for the Diagnosis of Coronary Artery Disease

MOM - Kwan Lee, MD

Pilot Study of Digital Health Intervention via Mobile Application for Improvement of Patient Compliance and Secondary Cardiovascular Outcomes in Patients Post Percutaneous Coronary Intervention

NP202-002 - Ranjith Shetty, MD

A Phase II Randomised, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety and Tolerability of Oral NP202 in Adults Who Have Left Ventricular Systolic Dysfunction Following Myocardial Infarction

PAH Biorepository - Ankit Desai, MD

National Biological Sample and Data Repository for Pulmonary Arterial Hypertension (WHO GROUP 1PAH)

PARACHUTE IV - Ranjith Shetty, MD and Mark Friedman, MD

A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System

PEARL - Karl B. Kern, MD 

What is The PEARL Study?

A Pilot Randomized Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography for Post-Cardiac Arrest Patients Without ECG ST Segment Elevation, called The PEARL Study for short, is evaluating the safety and effectiveness of coronary angiography (also known as heart catheterization) performed within 120 minutes of hospital arrival in a population of post-cardiac arrest patients without ST Segment elevation on their electrocardiograms (ECGs). This study will help answer the question: “Does an early heart catheterization improve cardiac arrest survival, regardless of what the ECG shows?”

Learn more on the PEARL Study webpage.

R01w Granzier & Khalpey - Elizabeth Juneman, MD

Myofilament Based Mechanisms of Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction (HFpEF)

SHC Heart Disease Databank & Biorepository - Nancy K. Sweitzer, MD, PhD

SHIELD II - Kapil Lotun, MD

HeartMate PHP™: Coronary InterventionS in HIgh-Risk PatiEnts Using a Novel Percutaneous Left Ventricular Support Device in Patients With Heart Failure


A prospective, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to assess the efficacy and safety of macitentan in patients with pulmonary hypertension after left ventricular assist device implantation

Sarver Heart Center iPSC - Nancy K. Sweitzer, MD, PhD

In Vivo Analysis of Cardiac Myocytes from Induced Pluripotent Stem Cells of Phenomapped Heart Failure with Preserved Ejection Fraction Patients

TEVA - Ranjith Shetty, MD

A Double-blind, Randomized, Sham-procedure-controlled, Parallel-group Efficacy and Safety Study of Allogeneic Mesenchymal Precursor Cells (CEP-41750) in Patients With Chronic Heart Failure Due to Left Ventricular Systolic Dysfunction of Either Ischemic or Nonischemic Etiology