Tucson Myofilament Meeting, May 23-26

The Tucson Myofilament Meeting is an international 3.5-day Sarver Heart Center conference that brings together approximately 250 scientists focused on the structure and function of the myofilaments that comprise the contractile machinery of muscle. Spanning topics from molecular biophysics to heart and skeletal muscle disease mechanisms and drug development, the meeting is known for its highly interactive, collaborative, and informal atmosphere, with strong engagement of early career investigators.

Traditionally held biennially at the University of Wisconsin, the meeting will continue at the University of Arizona beginning in May 2026, offering a distinctive Tucson setting that fosters scientific exchange and community building.

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College of Pharmacy Seminar: Functional Role of the High-Affinity Copper Transporter 1 (Ctr1) in Cisplatin-Induced Testicular Injury and Spermatogenesis

Tuesday, August 21, 2018 - 4:00pm to 5:00pm
Event Location: 

Skaggs Pharmaceutical Sciences Center (College of Pharmacy), room 325

Please join us for a seminar presented by Dr. Rashin Ghaffari, Postdoctoral Candidate from the Department of Cellular and Molecular Biology, University of Texas at Austin. Dr. Ghaffari's topic is "Functional Role of the High-Affinity Copper Transporter 1 (Ctr1) in Cisplatin-Induced Testicular Injury and Spermatogenesis."

Cisplatin (cDDP) is a highly effective chemotherapeutic drug that has adverse side effects, including prolonged azoospermia and infertility in male patients. The high-affinity membrane copper transporter 1 (CTR1; SCL31A1) is known to be involved in cDDP uptake and is highly expressed in the testes. Conditional knockout of Ctr1 in Sertoli cells (SCs) and in germ cells (GCs) were generated to examine the contribution of Ctr1 in cDDP-induced toxicity by each cell type. Results from these mice models revealed that (1) CTR1 is required for fertility in GCs but not in SCs and (2) cDDP uptake in SCs is independent of the CTR1 pathway.