Mohamed N Ahmed, MD

Education: 

• Suez Canal University, Ismailia, Egypt, (Medicine) 1987 (M.D.)
• Suez Canal University, Ismailia, Egypt/Duke Med. Ctr. Durham, NC, (Genetics) 1996-2002 (Ph.D)
• Duke Medical Center, Durham, NC, 1995-1998 (Medical Genetics, Fellowship) 
• Duke Medical Center, Durham, NC,  1998-2001 (Neonatology, Fellowship)
• University of Chapel Hill, NC  2001-2003 (Pediatrics, Resident)

Honors and Awards: 

• Innovation Award- Northwell Medical health system, Antileukinate and premature birth due to chorioamnionitis, A new drug to control chorioamnionitis among pregnant women. Role: PI  2017-2018
• Innovation Award- Northwell Medical health system, NEUROGUARD: AN INNOVATIVE SOLUTION FOR REDUCING PREMATURE BIRTHS, An innovative approach to control preterm labor. Role: PI  2017-2018
• United Therapeutic -Using neuromodulation as a therapeutic approach for pulmonary hypertension, Using VNS as alternative therapy for patients with PAH Role: PI   2015-2018
• Empire Clinical Research Investigator Program (ECRIP), Studying NO and other genes alleles among neonates and adults with PH, Developing PAH program among neonates and children, Cohen children at New York. Role: PI 2016-2018

Selected Publications: 

• Ahmed MN, Suliman H, Folz R, Grayck EN, Auten RL. Extracellular superoxide dismutase protects lung development in hyperoxic newborn mice. Am. J. Resp. Crit. Care Med. 167; 440-445, 2003. PMID: 12406846.
• Min J, Codipilly C, Miller E, Miller E, Ahmed MN. Synergistic Lung Protective Strategy by Blocking Neutrophil Influx by CXCR2 antagonist in Hyperoxia-Exposed hEC-SOD Transgenic Newborn Mice. Resp. Research 2012, 13:58. PMCID:PMC3441354. 
• Perveen S, Patel H, Arif A, Sharif Younis, Champa N. Codpilly C, Ahmed MN. Role of EC-SOD Over expression in Preserving Pulmonary Angiogenesis Inhibited by Oxidative Stress. PLoS ONE 7(12), 2012: e51945. doi:10.1371/journal.pone.0051945, 2012. PMID 23284826.
• Rajgarhia A, Ayyasola K, Zaghloul N, Lopez Da Re J, Miller E, Ahmed M. Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress. Frontiers in Cardiovasc Med., 31 May 2021. DOI: 10.3389/fcvm.2021.669975 PMID: 34136546 PMCID: PMC8202000
• Ahmed MN, Zhang Y, Codipilly C, et al.. EC-SOD overexpression can reverse the course of hypoxia-induced pulmonary hypertension in adult mice. Mol Med. 18(1):38-46, 2012. PMCID: PMC3269642.  
• Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, et al. Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase. Nat. Biotech, 34(10):1066-1071, 2016. PMCID: PMC5513182     
• Perveen S, Ayyasola K, Zagloul N, Patel H, Ochani K, Orner D, Benveniste H, Salerno M, Vaska P, Zuo Z, Alabed Y, Nasim M, Miller EJ, Ahmed M. MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia. Pediatr Res. 85(5):711-718; 2019. PMID: 30759452
• Sun X, Sun B, Babicheva S, Vandenpool R, Oita R, Casanova N, Tang H, Gupta A, Lynn H, Gupta G, Rischard F, Sammani S, Kempf C, Moreno-Vinasco L, Ahmed M, et al., Direct eNAMPT involvement in pulmonary hypertension and vascular remodeling:  Transcriptional regulation by SOX and HIF2α. Am J Respir Cell Mol Biol. Mar 6, 2020. doi: 10.1165/rcmb.2019-0164OC. PMID: 32142369
• Silverman H, Dancho M, Regnier-Golanov A, Nasim M, Ochani M, Olofsson P, Ahmed M, Miller E, Chavan S, Golanov E,  Metz C, Tracey K, Pavlov V. Brain Region-specific Alterations in the Gene Expression of Cytokines, Immune Cell Markers and Cholinergic System Components During Peripheral Endotoxin-induced Inflammation. Mol. Medicine, 20(1);601-611,2015. PMCID: PMC4365063
• Zaghloul N, Patel H, Ahmed, M. A model of Preventricular leukomalacia (PVL) in neonate mice with histopathological and neurodevelopmental outcomes mimicking PVL in neonates. PLOS one, 2017, 12(4): e0175438. PMCID:PMC5391059
• Zaghloul N, Addorisio ME, Silverman HA, Patel HL, Valdés-Ferrer SI, Ayasolla KR, Lehner KR, Olofsson PS, Nasim M, Metz CN, Wang P, Ahmed M, Chavan SS, Diamond B, Tracey KJ and Pavlov VA (2017) Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors. Front. Immunol. 8:1673, 2017. PMCID: PMC5736570
• Zaghloul N, Kurepa D, Bader M, Nagy N, Ahmed M. Prophylactic inhibition of NF-κB expression in microglia leads to attenuation of hypoxic ischemic injury of the immature brain. J Neuroinflammation 17, 365 (2020). doi.org/10.1186/s12974-020-02031-9
• kamity R, Patel H, Younis S, Miller EJ, Ahmed MN. Inhibition of CXCR1 and 2 Delays Preterm Delivery and Reduces Neonatal Mortality In a Mouse Model of Chorioamnionitis. European Journal of Inflammation. 2014; 12(3):447-457.
• Santoro GC, Shukla S, Patel K, Kaczmarzyk J, Agorastos S, Scherrer S, Choi YY, Veith C, Carrion J, Silverman R, Mullin D, Ahmed MN, Schiffer WK, Brodie JD, Dewey SL. A Novel Strategy for Attenuating Opioid Withdrawal in Neonates. J Addict Res Ther. 2016 Aug;7(4). pii: 291. PMCID: PMC5222617.
• Sheen W, Ahmed MN, Patel H, Codipilly C, Schanler R. Is the Antioxidant Capacity of Stored Human Milk Preserved? Breastfeeding Medicine J, Mar 15, 2021. PMID: 33728983 DOI: 10.1089/bfm.2020.0407.
• Bader MY, Zaghloul N, Repholz A, Nagy N, Ahmed MN, Thompson L, Kylat RI. A Retrospective Review Following the Addition of Clonidine to a Neonatal Abstinence Syndrome Treatment Algorithm. Front Pediatr. 2021;9:632836. doi: 10.3389/fped.2021.632836. eCollection 2021. PubMed PMID: 34164354; PubMed Central PMCID: PMC8215153

Patents: 

• The US Provisional application No. 62/419,530 - Filing date: November 9, 2016. It is entitled “Iguratimod as an MIF Inhibitor.”
• The US Provisional application  Pending - Filing date: 1/15/2020 by UA. It is entitled “System for treating pulmonary arterial hypertension through NEUROMODULATION”.
• The US Provisional application (Pending) - Filing date: 6/2020. It is entitled  “eNAMPT mAb for treatment of chorioamnionitis" UA20-256
• NIH Undergraduate Diversity Program: 
  • Vivek Aking, 2021, "Breeding Mice to Obtain Genes Through Genotyping and PCR"
• NIH High School Student Research Program: 
  • Amaya Noriega Ramirez, Salpointe Catholic High School, 2022
  • Alia Hernandez, Douglas High School, 2023