Sadek Lab

The Sadek Laboratory has a longstanding interest in understanding the mechanisms of cardiomyocyte cell cycle regulation as a means of enhancing the endogenous regenerative capacity of the myocardium. We also study mechanisms of contractile dysfunction and heart failure in various types of cardiomyopathies. 

Our goal is to develop safe, innovative, and accessible therapeutics. To this end, we leverage various genetic, metabolic, bioinformatic, biophysical and physiological approaches to identify novel and repurposed compounds for the treatment of heart failure.
 

Research Themes

Cardiac Regeneration

Understanding the mechanisms that regulate cardiomyocyte proliferation and endogenous myocardial regeneration

Cardiomyopathy Mechanisms

Investigating structural, metabolic, and molecular pathways that drive cardiomyopathy and heart failure

Drug Repurposing for Cardiovascular Disease

Identifying FDA-approved compounds capable of stimulating cardiac regeneration and reversing contractile dysfunction in cardiomyopathies.

Precision Cardiovascular Medicine

Developing patient-specific therapeutic strategies by linking mechanistic discoveries to clinical phenotypes

Publications

Recent publications from the Sadek Laboratory reflect ongoing work in cardiac regeneration, cardiomyocyte biology, and translational strategies to identify new therapies for heart disease.