Sadek Lab

Members of the Sadek Laboratory at the Sarver Heart Center.

The Sadek Laboratory studies the fundamental mechanisms that regulate cardiomyocyte cell cycle activity and myocardial regeneration. Our goal is to understand why the mammalian heart loses its ability to regenerate after birth and to identify strategies that can reactivate endogenous repair pathways in the adult heart.

Using a combination of molecular biology, genetics, metabolism, and translational cardiovascular research, our group investigates mechanisms of cardiomyocyte proliferation, cardiomyopathy, and heart failure. A major focus of the lab is the discovery of FDA-approved drugs that can be repurposed to promote cardiac regeneration and restore myocardial function.

Our long-term vision is to bridge clinical cardiology and basic science to develop precision therapies for patients with rare and currently untreatable cardiovascular diseases. 

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Research Themes

Cardiac Regeneration

Understanding the mechanisms that control cardiomyocyte proliferation and myocardial repair.

Cardiomyopathy Mechanisms

Investigating structural, metabolic, and molecular pathways that drive cardiomyopathy and heart failure.

Drug Repurposing for Cardiovascular Disease

Identifying FDA-approved compounds capable of stimulating cardiac regeneration and correcting genetic cardiomyopathies.

Precision Cardiovascular Medicine

Developing patient-specific therapeutic strategies by linking clinical phenotypes with mechanistic discoveries in the laboratory.

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Publications

Recent publications from the Sadek Laboratory reflect ongoing work in cardiac regeneration, cardiomyocyte biology, and translational strategies to identify new therapies for heart disease.

View Dr. Sadek's Publications on PubMed

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People

Principal Investigator

Faculty

Research Scholars

Visiting Scholars

Postdoctoral Fellows

Research Staff