Dr. Pappas' work is focused on understanding the mechanisms underlying actin filament assembly in striated muscle. Precise regulation of actin filament polarity, spacing and length is essential for proper muscle function and its dysregulation results in human myopathies. He's specifically interested in how actin-binding proteins that reside at the ends of the filament cooperate to regulate its architecture. His research utilizes a combination of cellular, genetic, biochemical, molecular and biomechanical approaches.
The Tucson Myofilament Meeting is an international 3.5-day Sarver Heart Center conference that brings together approximately 250 scientists focused on the structure and function of the myofilaments that comprise the contractile machinery of muscle. Spanning topics from molecular biophysics to heart and skeletal muscle disease mechanisms and drug development, the meeting is known for its highly interactive, collaborative, and informal atmosphere, with strong engagement of early career investigators.
Traditionally held biennially at the University of Wisconsin, the meeting will continue at the University of Arizona beginning in May 2026, offering a distinctive Tucson setting that fosters scientific exchange and community building.