Research in the Pires lab focuses on understanding the regulation of blood flow to the brain under normal and disease states. We are particularly interested in the communication between neurons, astrocytes (a type of glial cells) and endothelial cells that control blood flow to discrete regions of the cerebral cortex, a process called neurovascular coupling. Disease states, such as Alzheimer’s disease and hypertension, are known to alter neurovascular coupling in the brain, leading to improper blood flow delivery to neurons and, consequently, loss of brain cells and cognitive decline. Our lab studies particular receptors in endothelial cells that have their function diminished by Alzheimer’s disease and hypertension, and possible therapies that can improve their function.
The Tucson Myofilament Meeting is an international 3.5-day Sarver Heart Center conference that brings together approximately 250 scientists focused on the structure and function of the myofilaments that comprise the contractile machinery of muscle. Spanning topics from molecular biophysics to heart and skeletal muscle disease mechanisms and drug development, the meeting is known for its highly interactive, collaborative, and informal atmosphere, with strong engagement of early career investigators.
Traditionally held biennially at the University of Wisconsin, the meeting will continue at the University of Arizona beginning in May 2026, offering a distinctive Tucson setting that fosters scientific exchange and community building.
Paulo Pires, PhD
Assistant Professor, Physiology
Assistant Professor, Surgery
Research Interests:
Degrees:
PhD, Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan
MS, Cell and Structural Biology, Campinas State University, Sao Paulo, Brazil
BS, Biological Sciences, Sao Paulo State University, Sao Paulo, Brazil
Primary College, Department: